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- Title
Superiority of Protease Inhibitors over Nonnucleoside Reverse-Transcriptase Inhibitors when Highly Active Antiretroviral Therapy Is Resumed after Treatment Interruption.
- Authors
Barreiro, Pablo; de Mendoza, Carmen; González-Lahoz, Juan; Soriano, Vincent
- Abstract
Forty-five human immunodeficiency virus (HIV)-infected patients stopped taking treatment but resumed taking it thereafter. All 11 who resumed treatment with their prior protease inhibitor (PI)-based regimen reattained an undetectable virus load, whereas this occurred for only 15 (44%) of 34 patients who resumed nonnucleoside reverse-transcriptase inhibitor (NNRTI)-based treatment (P < .001). Distinct pharmacokinetics and resistance barriers may result in different performances for PIs and NNRTIs after treatment interruptions.
- Subjects
PROTEASE inhibitors; HIV-positive persons; ANTIVIRAL agents; CHEMICAL kinetics; DRUG metabolism; THERAPEUTICS
- Publication
Clinical Infectious Diseases, 2005, Vol 41, Issue 6, p897
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1086/432887