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- Title
Increases in CD3+CD4-CD8- T lymphocytes in AIDS patients with disseminated Mycobacterium avium-intracellulare complex infection.
- Authors
Moreau JF; Taupin JL; Dupon M; Carron JC; Ragnaud JM; Marimoutou C; Bernard N; Constans J; Texier-Maugein J; Barbeau P; Journot V; Dabis F; Bonneville M; Pellegrin JL; Moreau, J F; Taupin, J L; Dupon, M; Carron, J C; Ragnaud, J M; Marimoutou, C
- Abstract
Human immunodeficiency virus type 1 (HIV-1)-infected persons frequently have increased numbers of T cells bearing the gamma delta T cell receptor for antigen (gamma delta TCR). HIV-1-seropositive patients with < 100 CD4+ cells/mm3 were selected and divided into 9 AIDS-defining illness groups. The percentages of CD4+, CD8+, or double-negative CD4-CD8- (DN) T cells (most of the latter expressing the gamma delta TCR) for 8 symptomatic groups were compared with those for a reference group of asymptomatic HIV-1-infected patients. DN T cells were increased only in patients with disseminated Mycobacterium avium-intracellulare complex (MAC) infection, toxoplasmosis, or Kaposi's sarcoma. Multivariate logistic regression analysis revealed that the percentage of DN T cells was a better predictor of MAC infection than was the percentage of CD4+T cells. The increased percentage of DN T cells might have important implications for the understanding of gamma delta T cell physiology and for the early diagnosis and management of MAC infections in AIDS patients.
- Publication
Journal of Infectious Diseases, 1996, Vol 174, Issue 5, p969
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1093/infdis/174.5.969