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- Title
Immunoglobulin Prophylaxis against Human T Cell Lymphotropic Virus Type II in Rabbits.
- Authors
Morishita, Nobumasa; Ishii, Kazuyoshi; Tanaka, Yuji; Sawada, Takashi; Hoshino, Hiroo; Foung, Steven K. H.; Miyoshi, Isao
- Abstract
Hyperimmune globulins, I-IgG and II-IgG, prepared from healthy persons seropositive for human T cell lymphotropic virus (HTLV) types I and II, respectively, were tested for their prophylactic effect against HTLV-II infection in rabbits. Three groups (A, B, and C) of 3 female rabbits each were used. Group A rabbits were inoculated intravenously with HTLV-II-carrying rabbit lymphoid cell line RII. Group B and C rabbits were immunized, respectively,with II-IgG and I-IgG and challenged with RII cells 24 h later. All group A and C rabbits seroconverted for HTLV-II after 2 weeks, but all group B rabbits were protected from HTLV-II infection. Gene amplification by polymerase chain reaction revealed the presence of HTLV-II provirus sequences in all group A and C rabbits but in none of the group B rabbits. These findings indicate that passive immunization with II-IgG is effective in preventing HTLV-II infection and that there is no cross-neutralization between HTLV-I and -II.
- Publication
Journal of Infectious Diseases, 1994, Vol 169, Issue 3, p620
- ISSN
0022-1899
- Publication type
Article
- DOI
10.1093/infdis/169.3.620