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- Title
Self-reported visual dysfunction in multiple sclerosis: results from the 25-Item National Eye Institute Visual Function Questionnaire (VFQ-25).
- Authors
Balcer, Laura J.; Baier, Monika L.; Kunkle, Amy M.; Rudick, Richard A.; Weinstock-Guttman, Bianca; Simonian, Nancy; Galetta, Steven L.; Cutter, Gary R.; Maguire, Maureen G.
- Abstract
Visual impairment is one of the most common clinical manifestations of Multiple Sclerosis (MS), and is strongly related to overall health-related quality of life (HRQOL) in MS and other disorders. However, the assessment of vision-specific HRQOL in patients with MS has been limited. The purpose of this study was to examine self-reported visual dysfunction in a clinically heterogeneous MS cohort using the 25-Item National Eye Institute Visual Function Questionnaire (VFQ-25). The VFQ-25 was administered by telephone interview to a subset of participants in a follow-up study to a phase III trial of interferon β-1a for relapsing - remitting MS. Mean VFQ-25 composite scores and selected sub-scale scores were significantly lower (worse) among patients in our MS cohort (n=35) compared with a published reference group of patients with no history of chronic eye disease (n=118). These differences were observed despite a relatively younger age and tighter distribution of binocular visual acuities in the MS cohort. Patients with MS in this study thus demonstrated a greater degree of self-reported visual dysfunction, as measured by the VFQ-25, compared with an eye disease-free reference group. The VFQ-25 is a potentially useful measure of vision-specific HRQOL in patients with MS.
- Subjects
MULTIPLE sclerosis; EYE diseases; VISION disorders; VIRUS diseases; PEOPLE with visual disabilities; MYELIN sheath diseases
- Publication
Multiple Sclerosis (13524585), 2000, Vol 6, Issue 6, p382
- ISSN
1352-4585
- Publication type
Article
- DOI
10.1177/135245850000600604