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- Title
Effect of a Phosphodiesterase 3 Inhibitor, Cilostazol, on Bronchial Hyperresponsiveness in Elderly Patients with Asthma.
- Authors
Fujimura, Masaki; Kamio, Yumie; Myou, Shigeharu; Hashimoto, Takuma; Matsuda, Tamotsu
- Abstract
Background: Over the last few years, evidence has accumulated that cyclic nucleotide phosphodiesterase (PDE) 3 and/or PDE4 inhibitors may be useful for the treatment of asthma. The present study was designed to examine the effect of a selective orally active PDE3 inhibitor, cilostazol, on bronchial hyperresponsiveness (BHR) of asthma. Methods: The effect of a single oral dose of cilostazol on BHR was studied in 10 elderly patients with clinically stable asthma, with a mean age of 59.5 ± 4.8 years, in a double-blind, crossover, placebo-controlled study. Each subject received 100 mg of cilostazol, 200 mg of theophylline as a positive control or a placebo in a random order. The subjects underwent a methacholine challenge test 3 h after each drug administration on three occasions separated by 2 weeks. Results: The geometric mean value of the provocative concentration of methacholine causing a 20% fall in forced expiratory volume in 1 s (PC20-FEV1) with cilostazol was 0.48 mg/ml [geometric standard error of the mean (GSEM), 1.40] which was significantly (p < 0.01) greater than that with the placebo [0.25 mg/ml (GSEM, 1.36)]. The value with theophylline [0.32 mg/ml (GSEM, 1.54)] did not differ significantly from that with cilostazol or the placebo. Baseline forced vital capacity (FVC) and FEV1 values significantly (p < 0.05 and p < 0.001, respectively) increased with cilostazol from 2.73±0.25 and 1.52±0.17 to 2.86 ± 0.23 and 1.65±0.17 liters, respectively. Theophylline did not significantly increase the FVC or FEV1 value. Conclusion: It is suggested that the PDE3 inhibitor, cilostazol, has bronchodilator and bronchoprotective effects in elderly asthmatics. Copyright © 1997 S. Karger AG, Basel
- Publication
International Archives of Allergy & Immunology, 1997, Vol 114, Issue 4, p379
- ISSN
1018-2438
- Publication type
Article
- DOI
10.1159/000237698