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- Title
Genetic Control of Anti-Thyrotropin Receptor Antibody Generation in H-2<sup>K</sup> Mice Immunized with Thyrotropin Receptor-Transfected Fibroblasts.
- Authors
KEN-ICHI YAMAGUCHI; NAOKI SHIMOJO; SHUICHI KIKUOKA; AKIRA HOSHIOKA; AIZAN HIRAI; KAZUO TAHARA; KOHN, LEONARD D.; YOICHI KOHNO; HIROO NIIMI
- Abstract
We recently showed that immunization of AKR/N mice with murine fibroblasts transfected with the thyrotropin receptor (TSHR) and a murine major histocompatibility complex (MHC) class II molecule having the same H-2k haplotype, but not either alone, induces immune thyroid disease with the humoral and histological features of human Graves’, including the presence of two different TSHR antibodies (TSHRAbs): stimulating TSHRAbs which cause hyperthyroidism and thyrotropin-binding-inhibiting immunoglobulins (TBIIs). Immunization of 5 different mouse strains that share the H-2k haplotype, but differ in their genetic background, results in different TBII titers, indicating non-MHC genetic effect on TSHRAb formation. In addition, immunization of C3H/He mice induced TBII formation even in the absence of aberrant class II, unlike AKR/N mice. However, the mice did not develop hyperthyroxinemia characteristic of the presence of stimulating TSHRAbs. Aberrant class II expression is, therefore, necessary for the development of a full Graves’ syndrome with stimulating TSHRAbs; and immune recognition mechanisms by which TBIIs and stimulating TSHRAbs develop are differently regulated.
- Publication
Journal of Clinical Endocrinology & Metabolism, 1997, Vol 82, Issue 12, p4266
- ISSN
0021-972X
- Publication type
Article
- DOI
10.1210/jcem.82.12.4589