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- Title
Effects of Postmenopausal Hormone Replacement Therapy on HbA[sub1c] Levels.
- Authors
Okada, Mayumi; Nomura, Seiji; Ikoma, Yoko; Yamamoto, Eiko; Ito, Tomomi; Mitsui, Takashi; Tamakoshi, Koji; Mizutani, Shigehiko
- Abstract
OBJECTIVE — Estrogen seems to contribute to glucose homeostasis in women. The objective of this study was to examine the effects of hormone replacement therapy (HRT) on HbA[sub 1c] levels in Japanese postmenopausal women and to determine whether the effects varied with age. RESEARCH DESIGN AND METHODS — We studied 99 postmenopausal women taking HRT (mean ± SD age 56.5 ± 6.9 years, BM121.5 ± 2.3 kg/m²) and 101 postmenopausal women not on HRT (51.4 ± 6.1 years, 21.3 ± 2.4 kg/m²). HRT consisted of continuous conjugated equine estrogen (CEE; 0.625 mg/day) and medroxyprogesterone acetate (MPA; 2.5 mg/day) for >2 years. RESULTS — HbA[sub 1c] levels are positively associated with age and BMI in women who use HRT as well as in those who do not use HRT. After adjusting for age and BMI, HRT showed no effects on HbA[sub 1c] levels. However, HhA[sub 1c] levels were significantly lower in postmenopausal women aged 40-49 years who were taking HRT than in women of similar age who were not taking HRT (mean ± SE 4.776 ± 0.092 vs. 5.096 ± 0.078%, P < 0.05). No differences in HbA[sub 1c] levels between women who did and did not use HRT were observed in those older than 50 years. CONCLUSIONS — Oral HRT involving CEE combined with MPA may decrease HbA[sub 1c] levels in women aged 40-49 years and is likely to have no adverse effects on HbA[sub 1c] levels in women older than 50 years.
- Subjects
ESTROGEN; GLUCOSE; HORMONE therapy for menopause
- Publication
Diabetes Care, 2003, Vol 26, Issue 4, p1088
- ISSN
0149-5992
- Publication type
Article
- DOI
10.2337/diacare.26.4.1088