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- Title
Effects of a quick-release form of bromocriptine (Ergoset) on fasting and postprandial plasma glucose, insulin, lipid, and lipoprotein concentrations in obese nondiabetic hyperinsulinemic women.
- Authors
Kamath, Vinaya; Jones, Claire N.; Yip, Jeannie C.; Varasteh, Ben B.; Cincotta, Anthony H.; Reaven, Gerald M.; Chen, Yii-Der I.; Kamath, V; Jones, C N; Yip, J C; Varasteh, B B; Cincotta, A H; Reaven, G M; Chen, Y D
- Abstract
<bold>Objective: </bold>To assess the effect on various aspects of carbohydrate and lipid metabolism of administering a quick-release formulation of bromocriptine (Ergoset) to obese, nondiabetic, hyperinsulinemic women.<bold>Research Design and Methods: </bold>Hourly concentrations of prolactin, glucose, insulin, free fatty acid (FFA), and triglyceride were measured for 24 h before and after approximately 8 weeks of treatment with Ergoset. In addition, fasting lipid and lipoprotein concentrations and the steady-state plasma glucose (SSPG) concentration in response to a continuous infusion of somatostatin, insulin, and glucose were determined before and after Ergoset administration.<bold>Results: </bold>Circulating prolactin concentrations were dramatically decreased (P < 0.001) following treatment, associated with a significant fall (P < 0.05) in 24-h-long plasma glucose, FFA, and triglyceride concentrations. Neither circulating plasma insulin concentrations nor the ability of insulin to mediate glucose disposal changed with treatment. Finally, fasting total cholesterol fell (P < 0.05) and the ratio of total to HDL cholesterol decreased (P = 0.06) in association with Ergoset treatment.<bold>Conclusions: </bold>The fact that significant metabolic improvement was seen in the obese nondiabetic hyperinsulinemic women studied suggests that Ergoset could be of therapeutic benefit in clinical conditions of hyperglycemia and/or dyslipidemia.
- Publication
Diabetes Care, 1997, Vol 20, Issue 11, p1697
- ISSN
0149-5992
- Publication type
journal article
- DOI
10.2337/diacare.20.11.1697