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- Title
State of the Art in Trueness and Interlaboratory Harmonization for 10 Analytes in General Clinical Chemistry.
- Authors
Miller, W. Greg; Myers, Gary L.; Ashwood, Edward R.; Killeen, Anthony A.; Wang, Edward; Ehlers, Glenn W.; Hassemer, David; Lo, Stanley F.; Seccombe, David; Siekmann, Lothar; Thienpont, Linda M.; Toth, Alan
- Abstract
Context.-Harmonization and standardization of results among different clinical laboratories is necessary for clinical practice guidelines to be established. Objective.-To evaluate the state of the art in measuring 10 routine chemistry analytes. Design.-A specimen prepared as off-the-clot pooled sera and 4 conventionally prepared specimens were sent to participants in the College of American Pathologists Chemistry Survey. Analyte concentrations were assigned by reference measurement procedures. Participants.-Approximately 6000 clinical laboratories. Results.-For glucose, iron, potassium, and uric acid, more than 87.5% of peer groups meet the desirable bias goals based on biologic variability criteria. The remaining 6 analytes had less than 52% of peer groups that met the desirable bias criteria. Conclusions.-Routine measurement procedures for some analytes had acceptable traceability to reference systems. Conventionally prepared proficiency testing specimens were not adequately commutable with a fresh frozen specimen to be used to evaluate trueness of methods compared with a reference measurement procedure.
- Subjects
PATHOLOGICAL laboratories; CLINICAL medicine; PATHOLOGY; MEDICAL sciences; DIAGNOSIS
- Publication
Archives of Pathology & Laboratory Medicine, 2008, Vol 132, Issue 5, p838
- ISSN
0003-9985
- Publication type
Article
- DOI
10.5858/2008-132-838-sotait