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- Title
Surgical decompression improves recovery from neurological deficit and may provide a survival benefit in patients with diffuse large B-cell lymphoma-associated spinal cord compression: a case-series study.
- Authors
Ching-Ming Chang; Hung-Chieh Chen; Youngsen Yang; Ren-Ching Wang; Wen-Li Hwang; Chieh-Lin Jerry Teng
- Abstract
Background: Malignancy-associated spinal cord compression is generally treated by surgical decompression, radiotherapy or a combination of both. Since diffuse large B-cell lymphoma (DLBCL) is highly sensitive to both chemotherapy and radiotherapy, the role of surgical decompression in the treatment of DLBCL-associated spinal cord compression remains unclear. We therefore conducted a retrospective review to investigate the impact of surgical decompression on recovery from neurological deficit caused by DLBCL-associated spinal cord compression and patients' overall survival. Methods: Between March 2001 and September 2011, 497 newly diagnosed DLBCL patients were reviewed, and 11 cases had DLBCL-associated spinal cord compression. Six cases were treated surgically and five cases nonsurgically. Results: The rates of complete recovery from neurological deficit were 100% (6/6) and 20% (1/5) for patients in the surgical and nonsurgical groups, respectively (P = 0.015), while the median survival for patients in the surgical and nonsurgical groups was 48.6 months and 17.8 months, respectively (P = 0.177). Conclusions: We conclude that surgical decompression can improve recovery from neurological deficit in patients with DLBCL-associated spinal cord compression, possibly providing these patients a survival benefit.
- Subjects
SURGICAL decompression; NEUROLOGY; B cells; SPINAL cord; RADIOTHERAPY; CANCER chemotherapy; SPINAL cord compression
- Publication
World Journal of Surgical Oncology, 2013, Vol 11, Issue 1, p1
- ISSN
1477-7819
- Publication type
Article
- DOI
10.1186/1477-7819-11-90