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- Title
Citrus fruit intake and the risk of nasopharyngeal carcinoma.
- Authors
Xin-Xin Feng; Ming-Xu Wang; Ming Li; Xiao Tang; Hong Jiang; Rui Wang; Le Ma; Yue Yin; Chang-Rui Wu; Feng, Xin-Xin; Wang, Ming-Xu; Li, Ming; Tang, Xiao; Jiang, Hong; Wang, Rui; Ma, Le; Yin, Yue; Wu, Chang-Rui
- Abstract
<bold>Background and Objectives: </bold>Citrus fruit are suggested to be associated with reduced risk of nasopharyngeal carcinoma (NPC), but findings from epidemiologic studies have been inconsistent. We aimed to synthesize the association by conducting a meta-analysis of existing evidence.<bold>Methods and Study Design: </bold>Databases including Medline, EMBASE, Web of science, and the Cochrane Library were searched for eligible studies up to March 2019 using a series comprehensive searching terms. The adjusted odds ratios (ORs) of citrus fruit intake with NPC risk from each study were extracted to calculate a pooled association estimate with its 95% confidence interval (CI).<bold>Results: </bold>Nine studies totaling 3304 cases and 3850 controls were included in this analysis. Citrus fruit intake was significantly associated with reduced risk of NPC (OR: 0.72, 95% CI 0.58-0.91, p=0.005). In addition, this association tended to be stronger in Chinese (OR: 0.67, 95% CI 0.54-0.84, p<0.001). Dose-response analysis using cubic splines showed the risk of NPC decreased by 21% for citrus fruit intake of 4 times/week (OR: 0.79, 95% CI 0.66-0.94).<bold>Conclusions: </bold>Consumption of citrus fruit was associated with a significantly reduced risk of NPC, especially in Chinese.
- Subjects
CITRUS fruits; DATABASE design; CARCINOMA; META-analysis; ODDS ratio; CONFIDENCE intervals
- Publication
Asia Pacific Journal of Clinical Nutrition, 2019, Vol 28, Issue 4, p783
- ISSN
0964-7058
- Publication type
journal article
- DOI
10.6133/apjcn.201912_28(4).0015