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- Title
Michael addition of imidazole with acrylates catalyzed by alkaline protease from Bacillus subtilis in organic media.
- Authors
Ying Cai; Shi-Ping Yao; Qi Wu; Xian-Fu Lin
- Abstract
A new activity of alkaline protease from Bacillus subtilis for Michael addition reactions of imidazole, 4-nitro-1H-imidazole and 2-methyl-4-nitro-1H-imidazole with acrylates and acrylic acid was investigated. The reactions were carried out in pyridine at 50 °C for 72 h. Five N-substituted imidazole derivatives were obtained using acrylate esters, but not acrylic acid, in yields from 62% to 76%.
- Subjects
IMIDAZOLES; BACILLUS subtilis; BACILLUS (Bacteria); ACRYLIC acid; ESTERS; ORGANIC compounds
- Publication
Biotechnology Letters, 2004, Vol 26, Issue 6, p525
- ISSN
0141-5492
- Publication type
Article
- DOI
10.1023/B:BILE.0000019562.21256.39