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- Title
A convenient method for palladium-catalyzed reductive deuteration of organic substrates using deuterated hypophosphite in D<sub>2</sub>O.
- Authors
Oba, Makoto
- Abstract
A convenient method for the deuteration of organic substrates using deuterated hypophosphite as the deuterium source was investigated. Transfer deuteration of organic substrates, such as aromatic halides, alkenes, alkynes, epoxides, and O-benzyl derivatives, in the presence of palladium on carbon in deuterium oxide proceeded efficiently to give the corresponding deuterated products in excellent yields with high deuterium contents.
- Subjects
DEUTERATION; PALLADIUM catalysts; DEUTERIUM oxide; MASS spectrometry; HALIDES; ACIDIFICATION
- Publication
Journal of Labelled Compounds & Radiopharmaceuticals, 2015, Vol 58, Issue 5, p215
- ISSN
0362-4803
- Publication type
Other
- DOI
10.1002/jlcr.3277