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- Title
The major peripheral myelin protein zero gene: structure and localization in the cluster of Fcγ receptor genes on human chromosome 1q21.3 – q23.
- Authors
Pham-Dinh, Danielle; Fourbil, Yves; Blanquet, Francolse; Mattél, Marie-Geneviève; Roeckel, Nathalie; Latour, Philippe; Chazot, Guy; Vandenberghe, Antoon; Dautigny, André
- Abstract
We have characterized the human gene encoding the major peripheral myelin protein zero (PO) and assigned it, by hybridization, to the q21.3–q23 region of human chromosome 1. This region is known to contain a cluster of Interspersed genes coding for the related human leukocyte receptors of the Fc portion of the Immunoglobulin G (). This colocalization was refined by the finding of a yeast artificial chromosome (YAC) of the Centre d'Etude du Polymorphisme Humain (CEPH) library, hybridizing to the and genes, demonstrating their physical linkage. These data may have important implications in demyelinating diseases studies like Charcot — Marie — Tooth disease type 1B (CMT1B).
- Publication
Human Molecular Genetics, 1993, Vol 2, Issue 12, p2051
- ISSN
0964-6906
- Publication type
Article