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- Title
CYP-associated drug–drug interactions: A mission accomplished?
- Authors
Pelkonen, Olavi; Hakkola, Jukka; Hukkanen, Janne; Turpeinen, Miia
- Abstract
On the basis of official Finnish Medicines Authority (Fimea)-approved drug monographs, less than half of the approved small-molecule drugs between 2007 and 2016 were substrates, inhibitors or inducers of CYP enzymes, predominantly of CYP3A4. No significant unexpected, life-threatening, CYP-associated drug-drug interactions (CYP-DDIs) of newly approved drug entities have been observed in the last 10–15 years. The present analysis seems to suggest that tools to study and predict potentially significant CYP-DDIs are working and efficient.
- Subjects
CYTOCHROME P-450
- Publication
Archives of Toxicology, 2020, Vol 94, Issue 11, p3931
- ISSN
0340-5761
- Publication type
Editorial
- DOI
10.1007/s00204-020-02912-1