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- Title
High bone morphogenetic protein-15 level in follicular fluid is associated with high quality oocyte and subsequent embryonic development.
- Authors
Yan-Ting Wu; Li Tang; Jie Cai; Xiu-E Lu; Jian Xu; Xiao-Ming Zhu; Qiong Luo; He-Feng Huang
- Abstract
BACKGROUND Bone morphogenetic protein-15 (BMP-15) has been shown to influence oocyte maturation and quality. However, no relationship has been established between BMP-15 and oocyte quality/embryonic development in humans. The aim of this study is to investigate BMP-15 level in human follicular fluid (FF) and its possible role in determining oocyte quality and developmental potential. METHODS A total of 79 occytes and their corresponding FF from 79 women undergoing ICSI were examined. Individual oocytes were inseminated and subsequently assessed on the basis of their fertilization, cleavage and preimplantation development. BMP-15, FSH, estradiol (E2) and progesterone levels of FF were also analysed via the techniques of western blot or radioimmunoassay. RESULTS Higher FF BMP-15 levels were observed in the fertilized and cleaved groups versus the unfertilized and uncleaved groups, respectively (P P 2 levels in the same follicle. CONCLUSION The present study demonstrates that the BMP-15 level in FF appears to be a potential factor in predicting oocyte quality and subsequent embryo development, and is correlated with E2 level, which may additionally be a valuable predictor of oocyte fertilization.
- Subjects
BONE morphogenetic proteins; OVUM; EMBRYOLOGY; FERTILIZATION (Biology)
- Publication
Human Reproduction, 2007, Vol 22, Issue 6, p1526
- ISSN
0268-1161
- Publication type
Article
- DOI
10.1093/humrep/dem029