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- Title
Exposure to persistent organochlorine pollutants and seminal levels of markers of epididymal and accessory sex gland functions in Swedish men.
- Authors
A. Rignell-Hydbom; L. Rylander; S. Elzanaty; A. Giwercman; C.H. Lindh; L. Hagmar
- Abstract
BACKGROUND: A major exposure route for persistent organochlorine pollutants (POPs) in Sweden is through consumption of fatty fish from the Baltic Sea. Endocrine disruptors, such as POPs, may have a negative impact on sperm quality. The present study aimed to investigate whether exposure to 2,2′,4,4′,5,5′-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p′-DDE) affects epididymal and accessory sex gland function. METHODS: 157 fishermen from the coastal stretches of Sweden, aged 27–67 years, provided semen samples which were analyzed for prostate-specific antigen (PSA), neutral α-glucosidase (NAG), fructose and zinc levels. Serum levels of CB-153 and p′p-DDE were determined. RESULTS: The median CB-153 serum level was 189 ng/g lipid (range 40–1460) and a median p,p′-DDE serum level 231 ng/g lipid (range 40–2252). There was a significant linear association between CB-153 and total amount of PSA (slope [β]=−2.5, 95% confidence interval [CI] −4.0, −0.9; P=0.02). With age, abstinence time and smoking included in the model the association became non-significant (β=−1.4, 95% CI–3.0, 0.1; P=0.07). There were no significant associations between CB-153 and zinc, fructose and NAG. As for the exposure variable p,p′-DDE and the outcome variables, no significant associations were found. CONCLUSIONS: The study gives only very limited support of an association between CB-153 in serum and total PSA, and a random finding cannot be excluded.
- Subjects
ORGANOCHLORINE compounds; GONADS; PROSTATE-specific antigen; SERUM
- Publication
Human Reproduction, 2005, Vol 20, Issue 7, p1910
- ISSN
0268-1161
- Publication type
Article
- DOI
10.1093/humrep/deh856