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- Title
The dual role of the novel Wnt receptor tyrosine kinase, ROR2, in human carcinogenesis.
- Authors
Ford, Caroline E.; Qian Ma, Sean Si; Quadir, Ashfaque; Ward, Robyn L.
- Abstract
The Wnt signaling pathway is involved in the development and progression of many human cancers, yet attempts to target the pathway therapeutically have been disappointing to date. The recent discovery that the ROR2 receptor tyrosine kinase (RTK) is a novel Wnt receptor provides the potential to target the non-canonical Wnt pathway for cancer treatments. As a member of the RTK superfamily of surface receptors ROR2 appears to possess dual roles as a tumor suppressor or activator depending on tumor type. This review will explore the dual role of ROR2 in tumorigenesis and provide an up to date analysis of current literature in this rapidly expanding field.
- Publication
International Journal of Cancer, 2013, Vol 133, Issue 4, p779
- ISSN
0020-7136
- Publication type
Article
- DOI
10.1002/ijc.27984