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- Title
Design, development and optimization of immediate release tablet of deflazacort.
- Authors
Binu, Raina; Birendra, Shrivastava; Anurag, Bhargava; Shailesh, Sharma; Rai, Sharma Abhimanyu; Singh, Bajwa Prabhjot
- Abstract
The objective of the present study was to prepare immediate release tablets (IRTs) of deflazacort by direct compression method. Two types of superdisintegrants i.e. sodium starch glycolate (SSG) and Ac-Di-sol were used in the formulation of tablets. Twelve preliminary batches were prepared by varying the concentration of superdisintegrants. It was found that formulation containing Ac-Di-Sol disintegrated in less time as compared to formulation containing sodium starch glycolate. Values of friability was found to be more in case of formulation containing Ac-Di- Sol. Attempts were also made to prepare the tablets containing superdisintegrants in combination and these resulted in the formulation with improved values of disintegration time and friability. On the basis of preliminary studies optimization of IRT was done employing 32 full factorial design using design expert 7. The optimized batch of IRTs showed friability and disintegration time values of 0.598 and 64.17±3.50 respectively. It was also found that 96.26±1.82% of drug was released within 5 min.
- Subjects
FACTORIAL experiment designs; STARCH; DRUG development
- Publication
Journal of Drug Delivery & Therapeutics, 2019, Vol 9, Issue 2, p250
- ISSN
2250-1177
- Publication type
Article
- DOI
10.22270/jddt.v9i2.2411