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- Title
A Focus on Astrocyte Contribution to Parkinson's Disease Etiology.
- Authors
Prunell, Giselle; Olivera-Bravo, Silvia
- Abstract
Parkinson's disease (PD) is an incurable neurodegenerative disease of high prevalence, characterized by the prominent death of dopaminergic neurons in the substantia nigra pars compacta, which produces dopamine deficiency, leading to classic motor symptoms. Although PD has traditionally been considered as a neuronal cell autonomous pathology, in which the damage of vulnerable neurons is responsible for the disease, growing evidence strongly suggests that astrocytes might have an active role in the neurodegeneration observed. In the present review, we discuss several studies evidencing astrocyte implications in PD, highlighting the consequences of both the loss of normal homeostatic functions and the gain in toxic functions for the wellbeing of dopaminergic neurons. The revised information provides significant evidence that allows astrocytes to be positioned as crucial players in PD etiology, a factor that needs to be taken into account when considering therapeutic targets for the treatment of the disease.
- Subjects
PARKINSON'S disease; ETIOLOGY of diseases; DOPAMINERGIC neurons; SUBSTANTIA nigra; THERAPEUTICS; ASTROCYTES
- Publication
Biomolecules (2218-273X), 2022, Vol 12, Issue 12, p1745
- ISSN
2218-273X
- Publication type
Article
- DOI
10.3390/biom12121745