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- Title
Potential Therapeutic Options for COVID-19: Current Status, Challenges, and Future Perspectives.
- Authors
Sarkar, Chandan; Mondal, Milon; Torequl Islam, Muhammad; Martorell, Miquel; Docea, Anca Oana; Maroyi, Alfred; Sharifi-Rad, Javad; Calina, Daniela
- Abstract
The COVID-19 pandemic represents an unprecedented challenge for the researchers to offer safe, tolerable, and effective treatment strategies for its causative agent known as SARS-CoV-2. With the rapid evolution of the pandemic, even the off-label use of existing drugs has been restricted by limited availability. Several old antivirals, antimalarial, and biological drugs are being reconsidered as possible therapies. The effectiveness of the controversial treatment options for COVID-19 such as nonsteroidal antiinflammatory drugs, angiotensin 2 conversion enzyme inhibitors and selective angiotensin receptor blockers was also discussed. A systemic search in the PubMed, Science Direct, LitCovid, Chinese Clinical Trial Registry, and ClinicalTrials.gov data bases was conducted using the keywords "coronavirus drug therapy," passive immunotherapy for COVID-19', "convalescent plasma therapy," (CPT) "drugs for COVID-19 treatment," "SARS-CoV-2," "COVID-19," "2019-nCoV," "coronavirus immunology," "microbiology," "virology," and individual drug names. Systematic reviews, case presentations and very recent clinical guidelines were included. This narrative review summarizes the available information on possible therapies for COVID-19, providing recent data to health professionals.
- Subjects
COVID-19; MEDICAL personnel; NEPRILYSIN; COVID-19 pandemic; NONSTEROIDAL anti-inflammatory agents; SARS-CoV-2; ANTIVIRAL agents; ANTIMALARIALS
- Publication
Frontiers in Pharmacology, 2020, Vol 11, pN.PAG
- ISSN
1663-9812
- Publication type
Article
- DOI
10.3389/fphar.2020.572870