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Safe drugs with high potential to block malaria transmission revealed by a spleen-mimetic screening.
- Published in:
- Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-37359-2
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- Article
The Parasite Reduction Ratio (PRR) Assay Version 2: Standardized Assessment of Plasmodium falciparum Viability after Antimalarial Treatment In Vitro.
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- Pharmaceuticals (14248247), 2023, v. 16, n. 2, p. 163, doi. 10.3390/ph16020163
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- Article
Exploring a Tetrahydroquinoline Antimalarial Hit from the Medicines for Malaria Pathogen Box and Identification of its Mode of Resistance as PfeEF2.
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- ChemMedChem, 2022, v. 17, n. 22, p. 1, doi. 10.1002/cmdc.202200393
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- Article
Substituted Aminoacetamides as Novel Leads for Malaria Treatment.
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- ChemMedChem, 2019, v. 14, n. 14, p. 1329, doi. 10.1002/cmdc.201900329
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- Article
Structures revealing mechanisms of resistance and collateral sensitivity of Plasmodium falciparum to proteasome inhibitors.
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- Nature Communications, 2023, v. 14, n. 1, p. 1, doi. 10.1038/s41467-023-44077-2
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- Article
A New <i>In Vivo</i> Screening Paradigm to Accelerate Antimalarial Drug Discovery.
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- PLoS ONE, 2013, v. 8, n. 6, p. 1, doi. 10.1371/journal.pone.0066967
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- Article
P. falciparum In Vitro Killing Rates Allow to Discriminate between Different Antimalarial Mode-of-Action.
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- PLoS ONE, 2012, v. 7, n. 2, p. 1, doi. 10.1371/journal.pone.0030949
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- Article
Analysis of the DNA sequence of a 15,500 bp fragment near the left telomere of chromosome XV from Saccharomyces cerevisiae reveals a putative sugar transporter, a carboxypeptidase homologue and two new open reading frames.
- Published in:
- Yeast, 1996, v. 12, n. 7, p. 709, doi. 10.1002/(SICI)1097-0061(19960615)12:7<709::AID-YEA957>3.0.CO;2-1
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- Article
DNA sequence analysis of a 10 624 bp fragment of the left arm of chromosome XV from Saccharomyces cerevisiae reveals a RNA binding protein, a mitochondrial protein, two ribosomal proteins and two new open reading frames.
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- Yeast, 1996, v. 12, n. 10B, p. 1041, doi. 10.1002/(SICI)1097-0061(199609)12:10B<1041::AID-YEA989>3.0.CO;2-I
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- Article
XV. Yeast sequencing reports. DNA sequence analysis of a 13 kbp fragment of the left arm of yeast chromosome XV containing seven new open reading frames.
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- Yeast, 1995, v. 11, n. 13, p. 1281, doi. 10.1002/yea.320111308
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- Article
XV. Yeast sequencing reports. Sequence analysis of a 9873 bp fragment of the left arm of yeast chromosome XV that contains the ARG8 and CDC33 genes, a putative riboflavin synthase beta chain gene, and four new open reading frames.
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- Yeast, 1995, v. 11, n. 11, p. 1061, doi. 10.1002/yea.320111107
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- Article
Drug Screen Targeted at Plasmodium Liver Stages Identifies a Potent Multistage Antimalarial Drug.
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- Journal of Infectious Diseases, 2012, v. 205, n. 8, p. 1278, doi. 10.1093/infdis/jis184
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- Article
A human microdose study of the antimalarial drug GSK3191607 in healthy volunteers.
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- British Journal of Clinical Pharmacology, 2018, v. 84, n. 3, p. 482, doi. 10.1111/bcp.13476
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- Article
Thousands of chemical starting points for antimalarial lead identification.
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- Nature, 2010, v. 465, n. 7296, p. 305, doi. 10.1038/nature09107
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- Article
A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance.
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- Nature Communications, 2017, v. 8, n. 5, p. 15159, doi. 10.1038/ncomms15159
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- Article
A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue.
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- Nature Communications, 2017, v. 8, n. 2, p. 14574, doi. 10.1038/ncomms14574
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- Article
In vitro selection predicts malaria parasite resistance to dihydroorotate dehydrogenase inhibitors in a mouse infection model.
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- Science Translational Medicine, 2019, v. 11, n. 521, p. 1, doi. 10.1126/scitranslmed.aav1636
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- Article
A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria.
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- Science Translational Medicine, 2015, v. 7, n. 296, p. 1, doi. 10.1126/scitranslmed.aaa6645
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- Article
Phenotypic Screens, Chemical Genomics, and Antimalarial Lead Discovery.
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- PLoS Pathogens, 2011, v. 7, n. 8, p. 1, doi. 10.1371/journal.ppat.1002156
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- Article
Design and tests of prospective property predictions for novel antimalarial 2-aminopropylaminoquinolones.
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- Journal of Computer-Aided Molecular Design, 2020, v. 34, n. 11, p. 1117, doi. 10.1007/s10822-020-00333-x
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- Article
The antimalarial efficacy and mechanism of resistance of the novel chemotype DDD01034957.
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- Scientific Reports, 2021, v. 11, n. 1, p. 1, doi. 10.1038/s41598-021-81343-z
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- Article
A novel class of fast-acting antimalarial agents: Substituted 15-membered azalides.
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- 2021
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- journal article
A novel validated assay to support the discovery of new anti-malarial gametocytocidal agents.
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- Malaria Journal, 2016, v. 15, p. 1, doi. 10.1186/s12936-016-1429-9
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- Article
A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission.
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- Nature Communications, 2017, v. 8, n. 1, p. 1, doi. 10.1038/s41467-017-00572-x
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- Article
Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose-Efficacy Modeling.
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- 2016
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- journal article
Fueling Open-Source Drug Discovery: 177 Small-Molecule Leads against Tuberculosis.
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- ChemMedChem, 2013, v. 8, n. 2, p. 313, doi. 10.1002/cmdc.201200428
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- Article
Identifying rapidly parasiticidal anti-malarial drugs using a simple and reliable in vitro parasite viability fast assay.
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- Malaria Journal, 2015, v. 14, n. 1, p. 1, doi. 10.1186/s12936-015-0962-2
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- Article
Repositioning: the fast track to new anti-malarial medicines?
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- Malaria Journal, 2014, v. 13, n. 1, p. 1, doi. 10.1186/1475-2875-13-143
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- Article
Fueling Open Innovation for Malaria Transmission-Blocking Drugs: Hundreds of Molecules Targeting Early Parasite Mosquito Stages.
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- Frontiers in Microbiology, 2019, p. 1, doi. 10.3389/fmicb.2019.02134
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- Article
Machine learning-based phenotypic imaging to characterise the targetable biology of Plasmodium falciparum male gametocytes for the development of transmission-blocking antimalarials.
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- PLoS Pathogens, 2023, v. 19, n. 10, p. 1, doi. 10.1371/journal.ppat.1011711
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- Article