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- Title
LINGO1 variants in essential tremor and Parkinson's disease.
- Authors
Deng, H.; Gu, S.; Jankovic, J.
- Abstract
Deng H, Gu S, Jankovic J. LINGO1 variants in essential tremor and Parkinson's disease. Acta Neurol Scand: 2012: 125: 1-7 © 2011 John Wiley & Sons A/S. The leucine-rich repeat and Ig domain containing 1 gene ( LINGO1), recently considered to be conferred increased risk of essential tremor (ET), has been also implicated in Parkinson disease (PD). As the two common movement disorders have overlapping clinical and pathological features, it has been postulated that the LINGO1 gene may play a role in the pathogenesis of the two diseases. Here, we review published reports of the LINGO1 variants in ET and PD in an attempt to better understand the molecular and pathogenic relationship of LINGO1 to the two disorders.
- Subjects
PARKINSON'S disease; TREMOR; MOVEMENT disorders; HUMAN genetic variation; MOLECULAR biology; LEUCINE; PATHOGENIC microorganisms
- Publication
Acta Neurologica Scandinavica, 2012, Vol 125, Issue 1, p1
- ISSN
0001-6314
- Publication type
Article
- DOI
10.1111/j.1600-0404.2011.01516.x