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- Title
Effects of Levetiracetam Monotherapy on the Cognitive Function of Epilepsy Patients.
- Authors
Koo, Dae Lim; Hwang, Kyoung Jin; Kim, Daeyoung; Kim, You-Jin; Kim, Ji Young; Shin, Wonchul; Kim, Mi Rim; Joo, Eun Yeon; Lee, Jong-Min; Hong, Seung Bong
- Abstract
Aims: To estimate the effect of levetiracetam (LEV) on cognitive function and mood status in newly diagnosed epilepsy patients. Methods: Fifty-five drug-naïve epilepsy patients (M:F ratio = 31:24; mean age = 30.9 years) were included. All patients underwent two neuropsychological (NP) tests, one before receiving LEV and then another 12.9 ± 5.0 months after starting LEV monotherapy. We evaluated general cognitive function, verbal/visual attention and memory, linguistic and visuospatial functions, frontal lobe function, and mood status. Repeated-measures regression and generalized estimating equation models were applied to assess the effects of all the confounding variables such as seizure control, average LEV dose, duration of epilepsy, inter-test interval, and subtype of epilepsy syndrome. Results: LEV monotherapy over 1 year revealed significant improvements in the following domains of NP tests with the correction of possible confounding variables: verbal and visual attention, psychomotor speed, mental flexibility, executive function, verbal fluency and word generation. No NP domains showed any significant decrease. Conclusion: Our study suggested that LEV monotherapy had no harmful effect on cognitive function in drug-naïve patients with epilepsy. Copyright © 2013 S. Karger AG, Basel
- Subjects
FRONTAL lobe epilepsy; COGNITIVE ability; TREATMENT of epilepsy; PEOPLE with epilepsy; NEUROPSYCHOLOGICAL tests; REGRESSION analysis; UNILATERAL neglect; THERAPEUTICS
- Publication
European Neurology, 2013, Vol 70, Issue 1/2, p88
- ISSN
0014-3022
- Publication type
Article
- DOI
10.1159/000347230