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- Title
Glomerulopatía colapsante asociada a virus BK en un niño con síndrome nefrótico idiopático. Informe de un caso.
- Authors
Velásquez-Jones, Luis; Romero-Silva, Lillian; Ramón-García, Guillermo; Portillo-Carrillo, Martha; Portillo-Carrillo, Saúl; Valverde-Rosas, Saúl; Romero-Navarro, Benjamín; Valencia-Mayoral, Pedro
- Abstract
Background: focal segmental glomerulosclerosis (FSGS) is observed in about 10 % of children with idiopathic nephrotic syndrome; this disorder is usually resistant to corticoid therapy. In the last few years, five histological types of FSGS have been recognized; the collapsing nephropathy type is characterized by a rapid evolution to chronic renal failure. Clinical case: a four years old boy presented with an irrelevant past history; eight months before admission he developed idiopathic nephrotic syndrome. He was treated with steroids without improvement, and a renal biopsy was performed in which minimal glomerular changes were found. Despite combined immunosuppressive treatment, he developed renal failure, septic shock and death. Collapsing nephropathy was demonstrated by immunohistochemistry, light and electron microscopy; renal new human papovirus (BK) infection was also found in the postmortem study. Conclusions: collapsing nephropathy is an aggressive disorder resistant to immunosuppressive treatment, as occurred in our patient. Although some viral diseases have been associated with collapsing nephropathy, to our knowledge, BK infection has not been previously described in those patients.
- Subjects
JUVENILE diseases; NEPHROTIC syndrome; THERAPEUTICS; HISTOLOGY; KIDNEY diseases; CHRONIC kidney failure; PATIENTS
- Publication
Revista Medica del IMSS, 2009, Vol 47, Issue 1, p95
- ISSN
0443-5117
- Publication type
Article