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- Title
Optimal timing of renal replacement therapy initiation in acute kidney injury: the elephant felt by the blindmen?
- Authors
Chih-Chung Shiao; Tao-Min Huang; Spapen, Herbert D.; Honore, Patrick M.; Vin-Cent Wu; Shiao, Chih-Chung; Huang, Tao-Min; Wu, Vin-Cent
- Abstract
Renal replacement therapy (RRT) is a key component in the management of severe acute kidney injury (AKI) in critically ill patients. Many cohort studies, meta-analyses, and two recent large randomized prospective trials which evaluated the relationship between the timing of RRT initiation and patient outcome remain inconclusive due to substantial differences in study design, patient population, AKI definition, and RRT indication. A cause-specific diagnosis of AKI based on current staging criteria plus a sensitive biomarker (panel) that allows creating a homogeneous study population is definitely needed to assess the impact of early versus late initiation of RRT on patient outcome.
- Publication
Critical Care, 2017, Vol 21, p1
- ISSN
1364-8535
- Publication type
journal article
- DOI
10.1186/s13054-017-1713-2