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- Title
A corrosive oesophageal burn model in rats: Double-lumen central venous catheter usage.
- Authors
Bakan, Vedat; Çıralık, Harun; Kartal, Seyfi; Ciralik, Harun
- Abstract
<bold>Background: </bold>We aimed to create a new and less invasive experimental corrosive oesophageal burn model using a catheter without a gastric puncture (gastrotomy). <bold>Materials and Methods: </bold>We conducted the study with two groups composed of 8 male rats. The experimental oesophageal burn was established by the application of 10% sodium hydroxide to the distal oesophagus under a pressure of 20 cmH 2 O, via 5-F double-lumen central venous catheter without a gastrotomy. The control group was given 0.9% sodium chloride. All rats were killed 24 h after administration of NaOH or 0.9% NaCl. Histologic damage to oesophageal tissue was scored by a single pathologist blind to groups. <bold>Results: </bold>The rats in the control group were observed to have no pathological changes. Corrosive oesophagitis (tissue congestion, oedema, inflammation, ulcer and necrosis) was observed in rats exposed to NaOH. <bold>Conclusion: </bold>We believe that an experimental corrosive oesophageal burn can safely be created under same hydrostatic pressure without a gastric puncture using this model.
- Subjects
ESOPHAGUS diseases; INTRAVENOUS catheterization; STOMACH surgery; ANIMAL disease models; HALOTHERAPY; SODIUM hydroxide; THERAPEUTICS; ESOPHAGEAL injuries; PATHOLOGICAL physiology; ANIMAL experimentation; BIOLOGICAL models; BIOPSY; ESOPHAGOSCOPY; CHEMICAL burns; ESOPHAGUS; RATS; CENTRAL venous catheters; ESOPHAGEAL stenosis; DISEASE complications; DIAGNOSIS; EQUIPMENT &; supplies
- Publication
African Journal of Paediatric Surgery, 2015, Vol 12, Issue 4, p247
- ISSN
0189-6725
- Publication type
journal article
- DOI
10.4103/0189-6725.172560