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- Title
The association among MDCT-derived three-dimensional visceral adiposities on cardiac diastology and dyssynchrony in asymptomatic population.
- Authors
Yau-Huei Lai; Charles Jia-Yin Hou; Chun-Ho Yun; Kuo-Tzu Sung; Cheng-Huang Su; Tung-Hsin Wu; Fei-Shih Yang; Ta-Chuan Hung; Chung-Lieh Hung; Bezerra, Hiram G.; Hung-I Yeh; Lai, Yau-Huei; Hou, Charles Jia-Yin; Yun, Chun-Ho; Sung, Kuo-Tzu; Su, Cheng-Huang; Wu, Tung-Hsin; Yang, Fei-Shih; Hung, Ta-Chuan; Hung, Chung-Lieh
- Abstract
<bold>Background: </bold>Visceral adipose tissue, a biologically active fat depot, has been proposed as a reliable marker for visceral adiposity and metabolic abnormalities. Effects of such adiposity on LV diastolic function and dyssynchrony remained largely unknown.<bold>Methods: </bold>We assessed pericardial fat (PCF) and thoracic peri-aortic fat (TPAF) by three-dimensional (3D) volume-vender multi-detector computed tomography (MDCT) (Aquarius 3D Workstation, TeraRecon, San Mateo, CA, USA). Echo-derived diastolic parameters and tissue Doppler imaging (TDI) defined mitral annular systolic (S'), early diastolic (E') velocities as well as LV filling (E/E') were all obtained. Intra-ventricular systolic (Sys-D) and diastolic (Dias-D) dyssynchrony were assessed by TDI method.<bold>Results: </bold>A total of 318 asymptomatic subjects (mean age: 53.5 years, 36.8 % female) were eligible in this study. Greater PCF and TPAF were both associated with unfavorable diastolic indices and higher diastolic dyssynchrony (all p < 0.05). These associations remained relatively unchanged in multi-variate models. PCF and TPAF set at 81.68 & 8.11 ml yielded the largest sensitivity and specificity (78.6 and 60 % for PCF, 75 and 66.6 % for TPAF, respectively) in predicting abnormally high LV diastolic dyssynchrony, which was defined as Dias-D≧55 ms.<bold>Conclusion: </bold>Increasing visceral adiposity may be associated with adverse effects on myocardium, primarily featured by worse diastolic function and greater degree of dyssynchrony.
- Subjects
ADIPOSE tissue physiology; HEART ventricle diseases; HUMAN body composition; DIASTOLE (Cardiac cycle); ECHOCARDIOGRAPHY; LEFT heart ventricle; OBESITY; SYMPTOMS; MULTIDETECTOR computed tomography
- Publication
BMC Cardiovascular Disorders, 2015, Vol 15, Issue 1, p1
- ISSN
1471-2261
- Publication type
journal article
- DOI
10.1186/s12872-015-0136-8