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- Title
The in vitro study of interaction between antacids and anti-diabetic drug sitagliptin in the treatment of type II diabetes.
- Authors
Tabassum, Nargis; Akram, Arfa; Azizuddin; Ahmed, Ateka; Khan, Muhammad Naseem; Khan, Rashid Ali; Azeem, Iffat; Furrukh, Mehwish
- Abstract
Hyperglycemia is a long-lasting syndrome that occurs either when the pancreas cannot produce enough insulin, or the body cannot effectively utilize that insulin to regulate blood sugar levels. Non-insulin-dependent hyperglycemia, also known as type II diabetes, causes a common consequence of severe damage to many of the body's organs mainly the blood vessels and nerves. The majority of people around the world are suffering from non-insulindependent diabetes. The present work showed a great effort to investigate any possible interaction between antacids and sitagliptin (anti-diabetic drug) in the treatment of type II diabetes with gastrointestinal tract problems. The in vitro studies were carried out in simulated gastric juice pH 2.0 and intestinal pH 7.4 at 37°C. MgCO3, NaHCO3, Mg(OH)2, Al(OH)3 and CaCO3 were used as antacids in these studies. It has been observed that % release of sitagliptin was significantly enhanced in the presence of calcium carbonate and magnesium carbonates.
- Subjects
TYPE 2 diabetes; HYPERGLYCEMIA; SITAGLIPTIN; ANTACIDS; BLOOD sugar; IN vitro studies
- Publication
Pakistan Journal of Pharmaceutical Sciences, 2023, Vol 36, Issue 2, p373
- ISSN
1011-601X
- Publication type
Article
- DOI
10.36721/PJPS.2023.36.2.REG.373-378.1