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- Title
Increased ERCC1 expression is linked to chromosomal aberrations and adverse tumor biology in prostate cancer.
- Authors
Jacobsen, Frank; Taskin, Billurvan; Melling, Nathaniel; Sauer, Charlotte; Wittmer, Corinna; Hube-Magg, Claudia; Kluth, Martina; Simon, Ronald; Pehrke, Dirk; Beyer, Burkhard; Steuber, Thomas; Thederan, Imke; Sauter, Guido; Schlomm, Thorsten; Wilczak, Waldemar; Möller, Katharina; Weidemann, Sören A.; Burdak-Rothkamm, Susanne
- Abstract
<bold>Background: </bold>Animal model experiments have suggested a role of the DNA repair protein ERCC1 (Excision Repair Cross-Complementation Group 1) in prostate cancer progression.<bold>Methods: </bold>To better understand the impact of ERCC1 protein expression in human prostate cancer, a preexisting tissue microarray (TMA) containing more than 12,000 prostate cancer specimens was analyzed by immunohistochemistry and data were compared with tumor phenotype, PSA recurrence and several of the most common genomic alterations (TMPRSS2:ERG fusions: deletions of PTEN, 6q, 5q, 3p).<bold>Results: </bold>ERCC1 staining was seen in 64.7% of 10,436 interpretable tissues and was considered weak in 37.1%, moderate in 22.6% and strong in 5% of tumors. High-level ERCC1 staining was linked to advanced pT stage, high Gleason grade, positive lymph nodes, high pre-operative serum PSA, and positive surgical margin status (p < 0.0001 each). High ERCC1 expression was strongly associated with an elevated risk of PSA recurrence (p < 0.0001). This was independent of established prognostic features. A subgroup analysis of cancers defined by comparable quantitative Gleason grades revealed that the prognostic impact was mostly driven by low-grade tumors with a Gleason 3 + 3 or 3 + 4 (Gleason 4: ≤5%). High ERCC1 expression was strongly associated with the presence of genomic alterations and expression levels increased with the number of deletions present in the tumor. These latter data suggest a functional relationship of ERCC1 expression with genomic instability.<bold>Conclusion: </bold>The results of our study demonstrate that expression of ERCC1 - a potential surrogate for genomic instability - is an independent prognostic marker in prostate cancer with particular importance in low-grade tumors.
- Subjects
DNA repair; PROTEINS; CHROMOSOME abnormalities; TUMORS; PROSTATE cancer; PROTEIN metabolism; BLOOD coagulation factors; CELL physiology; ESTERASES; MULTIVARIATE analysis; GENETIC mutation; PROGNOSIS; PROSTATE tumors; DNA-binding proteins; PROSTATE-specific antigen; PROPORTIONAL hazards models; DISEASE progression; KAPLAN-Meier estimator; TUMOR grading
- Publication
BMC Cancer, 2017, Vol 17, p1
- ISSN
1471-2407
- Publication type
journal article
- DOI
10.1186/s12885-017-3489-9