We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
A case of primary ovarian lymphoma with autoimmune hemolytic anemia achieving complete response with Rituximab-based combination chemotherapy.
- Authors
Ghadyalpatil, N. S.; Chandrasekar, R.; Snehalatha, D.; Reddy, B. M.
- Abstract
Ovarian involvement as primary or secondary lymphomatous process is extremely uncommon. In most cases, the diagnosis is usually not suspected initially and is confirmed only after detailed histopathological evaluation. We report a patient with primary ovarian diffuse large B-cell lymphoma (DLBCL) and associated auto-immune hemolytic anemia (AIHA) who achieved complete remission after treatment with Rituximab-cyclophosphamide-doxorubicin-vincristine and prednisolone (R-C HOP) chemotherapy. This patient was a 50 year old female, who presented with fever, abdominal pain, vomiting, weight loss and anemia. Computed tomography scan of the abdomen and pelvis revealed a large left ovarian mass with bilateral hydronephrosis. We performed exploratory laparotomy and partial resection of the mass was done due to the adhesions. Histopathology confirmed the diagnosis of DLBCL. After six R-CHOP chemotherapy cycles, patient achieved complete response with correction of anemia. To our knowledge, this may be the first case report till date of primary ovarian DLBCL with AIHA treated with R-CHOP chemotherapy who achieved complete remission in terms of primary disease as well as hemolytic anemia.
- Subjects
OVARIAN cancer treatment; OVARIAN cancer diagnosis; AUTOIMMUNE hemolytic anemia; RITUXIMAB; CANCER chemotherapy; TOMOGRAPHY; HISTOPATHOLOGY; DISEASES in older women
- Publication
Indian Journal of Medical & Paediatric Oncology, 2011, Vol 32, Issue 4, p207
- ISSN
0971-5851
- Publication type
Article
- DOI
10.4103/0971-5851.95142