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- Title
In Vitro Investigation of the Anticancer Properties of Ammodaucus Leucotrichus Coss. & Dur.
- Authors
Lenzi, Monia; Turrini, Eleonora; Catanzaro, Elena; Cocchi, Veronica; Guerrini, Alessandra; Hrelia, Patrizia; Gasperini, Sofia; Stefanelli, Claudio; Abdi Bellau, Mohamed Lamin; Pellicioni, Valentina; Tacchini, Massimo; Greco, Giulia; Fimognari, Carmela
- Abstract
Little is known about the pharmacological activity of Ammodaucus leucotrichus Coss. & Dur., a small annual species that grows in the Saharan and sub-Saharan countries. In the present study, we investigated whether the standardized ethanolic extract of A. leucotrichus fruits and R-perillaldehyde, a monoterpenoid isolated from A. leucotrichus fruits, are able to affect different processes involved in different phases of cancer development. In particular, we explored their genoprotective, proapoptotic, antiproliferative, and cytodifferentiating potential on different human cell models. We analyzed the genoprotective and proapoptotic activity on human lymphoblast cells (TK6) using the micronucleus test, and the cytodifferentiation effects on human promyelocytic cells (HL60) through the evaluation of different markers of differentiation forward granulocytes or monocytes. The results showed that the extract and perillaldehyde were able to induce apoptosis and protect from clastogen-induced DNA damage. To our best knowledge, this is the first report on the ability of A. leucotrichus and perillaldehyde to induce apoptosis and protect DNA from the toxicity of different compounds. Data reported in this work are the starting point for their pharmacological use. Going forward, efforts to determine their effects on other events associated with cancer development, such as angiogenesis and metastasization, will provide important information and improve our understanding of their potential in cancer therapy.
- Subjects
DNA damage; CARCINOGENESIS; CANCER treatment; GRANULOCYTES; FRUIT development; NUCLEOLUS; GENETIC toxicology
- Publication
Pharmaceuticals (14248247), 2022, Vol 15, Issue 12, p1491
- ISSN
1424-8247
- Publication type
Article
- DOI
10.3390/ph15121491