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- Title
Comprehensively understanding fatigue in patients with myeloproliferative neoplasms.
- Authors
Scherber, Robyn M.; Kosiorek, Heidi E.; Senyak, Zhenya; Dueck, Amylou C.; Clark, Matthew M.; Boxer, Michael A.; Geyer, Holly L.; McCallister, Archie; Cotter, Mary; Van Husen, Barbara; Harrison, Claire N.; Mesa, Ruben A.
- Abstract
<bold>Background: </bold>Patients with myeloproliferative neoplasms (MPNs) experience a high persistence, prevalence, and severity of fatigue. There is currently only limited information regarding factors that contribute to fatigue in patients with MPNs.<bold>Methods: </bold>A 70-item, Internet-based survey regarding fatigue was developed by MPN investigators and patients/advocates and hosted by the Mayo Clinic Survey Research Center.<bold>Results: </bold>Fatigue was found to be prevalent and severe among international survey respondents (1788 respondents). Higher body mass index (P<.001), current use of alcohol (P<.001), and current tobacco use (P = .0025) were found to be significantly associated with greater fatigue. Moderate/severe fatigue was present more frequently in those individuals who did not exercise compared with those who reported exercising at least once per week (P<.001). Medical comorbidities found to be significantly associated with greater fatigue included restless leg syndrome (P = .006), diabetes mellitus (P = .045), fibromyalgia (P < 0.001), chronic fatigue syndrome (P = .006), and chronic kidney disease (P = .02). Current use of antidepressants (P<.001), antihistamines (P = .0276), antianxiety medications (P = .0357), and prescription pain medications (P<.001) were found to be associated with worsened fatigue. Nearly 25% of respondents scored > 2 on the Patient Health Questionnaire, indicating a high probability of depression. Higher Brief Fatigue Inventory score, Myeloproliferative Neoplasm Total Symptom Score, and individual symptom items were all associated with a higher likelihood of depressive symptoms (P<.0001).<bold>Conclusions: </bold>The management of fatigue should be multifactorial, with a comprehensive assessment and treatment plan to address all modifiable fatigue etiologies. Patients with MPNs likely have a higher prevalence of mood disturbances compared with the general population, suggesting the need to assess and intervene in this domain.
- Subjects
TUMORS; FATIGUE (Physiology); EPIDEMIOLOGY of cancer; SEVERITY of illness index; SYMPTOMS; ANXIETY treatment; THERAPEUTICS; DIABETES complications; FATIGUE prevention; AFFECTIVE disorders; ANXIETY; BEHAVIOR; BONE marrow cancer; CHRONIC diseases; CHRONIC fatigue syndrome; MENTAL depression; FIBROMYALGIA; INTERNET; QUALITY of life; SELF-evaluation; RESTLESS legs syndrome; COMORBIDITY; DISEASE complications; PSYCHOLOGY
- Publication
Cancer (0008543X), 2016, Vol 122, Issue 3, p477
- ISSN
0008-543X
- Publication type
journal article
- DOI
10.1002/cncr.29753