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- Title
Phase II Study of Topotecan in Combination With Dexamethasone, Asparaginase, and Vincristine in Pediatric Patients With Acute Lymphoblastic Leukemia in First Relapse.
- Authors
Hijiya, Nobuko; Stewart, Clinton F.; Yinmei Zhou; Campana, Dario; Coustan-Smith, Elaine; Rivera, Gaston K.; Relling, Mary V.; Ching-Hen Pui; Gajjar, Amar
- Abstract
The article presents a phase II study on the response rate, toxicity and pharmacokinetics of topotecan given before standard induction therapy for childhood acute lymphoblastic leukemia (ALL) in first relapse. It showed the effectiveness of a regimen that includes a single-agent topotecan with a standard 3-drug combination in inducing remission in pediatric patients with relapsed ALL.
- Subjects
CAMPTOTHECIN; PHARMACOKINETICS; LYMPHOBLASTIC leukemia in children; DISEASE relapse; DRUG efficacy
- Publication
Cancer (0008543X), 2008, Vol 112, Issue 9, p1983
- ISSN
0008-543X
- Publication type
Article
- DOI
10.1002/cncr.23395