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- Title
Impaired resistance to <em>Listeria monocytogenes</em> in mice chronically exposed to cadmium.
- Authors
Simonet, M.; Berche, P.; Fauchere, J. L.; Vero, M.
- Abstract
It is shown in this work that resistance to Listeria monocytogenes is greatly impaired in C57BL/6 mice chronically exposed to cadmium (CA) chloride. Animals received 0.5 mg/kg Cd by an intraperitoneal route three times a week during a 4-week period and were then infected with L. monocytogenes. Susceptibility to this pathogenic bacteria was not due to a defect of the specific immune response, since mice developed normal levels of anti-Listeria T cell-mediated immunity and did not show any impairment of macrophage activation. In fact, bacterial growth in organs was rapid in CA-exposed mice during the early phase of infection, suggesting an impairment of non-specific defence mechanisms. Experimental data indicate that the susceptibility to L. monocytogenes might be due to a defect of macrophage recruitment in sites of infection during the early phase of the host response.
- Subjects
LISTERIA monocytogenes; CADMIUM; LISTERIA; IMMUNE response; IMMUNOLOGY; PATHOGENIC bacteria
- Publication
Immunology, 1984, Vol 53, Issue 1, p155
- ISSN
0019-2805
- Publication type
Article