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- Title
A quantitative analysis of long-term follow-up computed tomography of idiopathic pulmonary fibrosis: the correlation with the progression and prognosis.
- Authors
Kunihiro, Yoshie; Matsumoto, Tsuneo; Murakami, Tomoyuki; Shimokawa, Mototsugu; Kamei, Haruhito; Tanaka, Nobuyuki; Ito, Katsuyoshi
- Abstract
Background: Quantitative analyses of computed tomography (CT) images using computer-aided detection (CAD) are correlated with visual assessments and pulmonary function test findings and might be useful for predicting the prognosis of patients with idiopathic pulmonary fibrosis (IPF). Purpose: To evaluate the association between the quantitative analysis of long-term follow-up CT of IPF and the progression and prognosis. Material and Methods: A total of 48 patients with IPF who received over one year of follow-up CT were included in this study. The results of quantitative analyses (emphysema, ground-glass attenuation [GGA], consolidation, reticulation, and honeycombing) using a CAD software program of initial and follow-up CT findings were evaluated, and the association with the progression of the total lesion of IPF and prognosis using Spearman's rank correlation and Cox regression analyses was considered. Results: Results of quantitative analyses of consolidation, reticulation, honeycombing, and the total lesion on initial CT were correlated with progressive changes in the total lesion of IPF per year (r = 0.4375, 0.4128, 0.4649, and 0.4095, respectively). The results of quantitative analyses of honeycombing (hazard ratio [HR] = 1.40, 95% confidence interval [CI] = 1.03−1.89, P = 0.0314) and GGA (HR = 0.85, 95% CI = 0.72−0.99, P = 0.0384) at initial CT were prognostic factors according to a multivariate Cox regression analysis. Conclusion: The quantitative analysis of honeycombing using a CAD software program of CT findings may be useful for predicting the progression and prognosis of patients with IPF.
- Subjects
COMPUTER-aided diagnosis; QUANTITATIVE research; COMPUTED tomography; COMPUTER-aided design software; PULMONARY function tests; IDIOPATHIC pulmonary fibrosis
- Publication
Acta Radiologica, 2023, Vol 64, Issue 8, p2409
- ISSN
0284-1851
- Publication type
Article
- DOI
10.1177/02841851231175252