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- Title
Magnetic resonance evaluation of cerebral toxoplasmosis in patients with the acquired immunodeficiency syndrome.
- Authors
Batra, A.; Tripathi, R.P.; Gorthi, S.P.
- Abstract
<bold>Purpose: </bold>To evaluate and delineate the characteristics of cerebral toxoplasmosis lesions using a combination of magnetic resonance (MR) spectroscopy, diffusion, and perfusion studies.<bold>Material and Methods: </bold>A total of 8 patients with 23 lesions were evaluated on a 1.5-T MR system. Diffusion-weighted imaging (DWI) was performed with three 'b' values of 50, 500, and 1000 s/mm2, and the apparent diffusion coefficient maps were calculated. The diffusion-weighted appearances and the T2-weighted MR appearances of the lesions were compared. MR spectroscopy was performed using the point-resolved single-voxel technique with two TE values of 135 ms and 270 ms. Perfusion studies were carried out using the dynamic contrast-enhanced technique, and the relative cerebral blood volume maps were qualitatively and quantitatively analyzed.<bold>Results: </bold>DWI revealed the majority of the lesions as having increased diffusion within their necrotic centers, with the ADC ranging from 0.5 to 3.01 (mean +/- SD: 1.49 +/- 0.7). All the lesions revealed a predominant lipid peak on MR spectroscopy and were extremely hypovascular on perfusion MR studies.<bold>Conclusion: </bold>MR diffusion, spectroscopy, and perfusion studies help in characterizing toxoplasmosis lesions and, in most cases, can be used in combination to help establish the diagnosis of toxoplasmosis.
- Subjects
MAGNETIC resonance; TOXOPLASMOSIS; BRAIN diseases; AIDS; SPECTRUM analysis; CEREBRAL circulation; DIFFERENTIAL diagnosis; MAGNETIC resonance imaging; AIDS-related opportunistic infections; CEREBRAL toxoplasmosis
- Publication
Acta Radiologica, 2004, Vol 45, Issue 2, p212
- ISSN
0284-1851
- Publication type
journal article
- DOI
10.1080/02841850410003969