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- Title
Failure of PTH, Calcitonin, or Vitamin D Metabolites to Influence Calcium Transport in the Maturation Stage Enamel Organ.
- Authors
BAWDEN, J. W.; DEATON, T. G.; TIMKO, D. A.; CRENSHAW, M. A.
- Abstract
Eleven-day-old rat maxillary first molar explants were removed by microdissection and incubated in vitro to determine the direct effects of parathyroid hormone (PTH), calcitonin (CT), 1,25(OH)2D3, 24,25(OH) 2D3, and a combination of PTH and vitamin D3 metabolites on calcium uptake in the mineralizing enamel of the explants. None of the agents had a statistically significant effect. These results are in contrast to those observed on explants from six-day-old rats, where PTH + 24,25(OH) 2D3 caused a significant increase in net calcium transport. The findings are consistent with the hypothesis that the transcellular transport of calcium through the secretary stage and the maturation stage ameloblasts occurs by different mechanisms.
- Subjects
DENTAL enamel; LABORATORY rats; METABOLITES; PARATHYROID hormone; CALCITONIN; VITAMIN D; ANIMAL models in research; BIOMINERALIZATION; CELL communication; BIOLOGICAL transport; CALCIUM
- Publication
Journal of Dental Research, 1985, Vol 64, Issue 9, p1138
- ISSN
0022-0345
- Publication type
Article
- DOI
10.1177/00220345850640090801