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- Title
Enhanced Coupling Within Gonadotropic and Adrenocorticotropic Axes by Moderate Exercise in Healthy Men.
- Authors
Roelfsema, Ferdinand; Yang, Rebecca J; Olson, Thomas P; Joyner, Michael J; Takahashi, Paul Y; Veldhuis, Johannes D
- Abstract
<bold>Context: </bold>Exercise elicits incompletely defined adaptations of metabolic and endocrine milieu, including the gonadotropic and corticotropic axes.<bold>Objective: </bold>To quantify the impact of acute exercise on coordinate luteinizing hormone (LH) and testosterone (T) and adrenocorticotropic hormone (ACTH) and cortisol secretion in healthy men in relation to age.<bold>Participants and Design: </bold>Prospectively randomized, within-subject crossover study in 23 men aged 19 to 77 years old. Subjects underwent rest and 30 minutes of mixed exercise at 65% of maximal aerobic capacity with 10-minute blood sampling between 7:00 am and 1:00 pm, 2 weeks apart.<bold>Main Outcome Measures: </bold>Incremental changes in LH, T, ACTH, and cortisol concentrations, the feedforward and feedback strength between exercise and rest, quantified by approximate entropy (ApEn), and bihormonal synchrony, quantitated by cross-ApEn.<bold>Results: </bold>Mean hourly exercise-minus-rest LH and ACTH increments increased from -0.055 ± 0.187 to 0.755 ± 0.245 IU/L (P = 0.003) and from 2.9 ± 2.2 to 71.2 ± 16.1 ng/L (P < 0.0001), respectively, during exercise. T and cortisol increments increased concurrently from -9.6 ± 16.7 to 47.6 ± 17.1 ng/dL (P < 0.0001) and 0.45 ± 0.76 to 7.27 ± 0.64 µg/dL (P < 0.0001), respectively. During exercise, feedforward and feedback LH-T and ACTH-cortisol cross-ApEn decreased markedly quantifying enhanced hormonal coupling.<bold>Conclusions: </bold>Acute moderate mixed exercise in healthy men rapidly enhances feedforward LH-T and ACTH-cortisol coordination and reciprocal feedback within the gonadotropic and corticotropic axes. In principle, enhancement of both LH-T and ACTH-cortisol secretory synchrony by exercise could reflect augmented coupling between brain-testicular and brain-adrenal neural outflow.
- Subjects
ADRENOCORTICOTROPIC hormone; ANTHROPOMETRY; BODY composition; COMPARATIVE studies; CROSSOVER trials; EXERCISE; LONGITUDINAL method; LUTEINIZING hormone; RESEARCH methodology; MEDICAL cooperation; REFERENCE values; RESEARCH; STATISTICAL sampling; EVALUATION research; BODY mass index; RANDOMIZED controlled trials; HUMAN research subjects; EXERCISE tolerance
- Publication
Journal of Clinical Endocrinology & Metabolism, 2017, pN.PAG
- ISSN
0021-972X
- Publication type
journal article
- DOI
10.1210/jc.2017-00036