We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Antioxidant activity of linalool in patients with carpal tunnel syndrome.
- Authors
Geun-Hye Seol; Purum Kang; Hui Su Lee; Geun Hee Seol; Seol, Geun-Hye; Kang, Purum; Lee, Hui Su; Seol, Geun Hee
- Abstract
<bold>Background: </bold>Carpal tunnel syndrome (CTS) is a common peripheral neuropathy and ischemic-reperfusion injury. Oxidative stress is considered a major cause of CTS. Linalool, a component of essential oils, has antioxidant activity. This study was designed to determine the effects of linalool inhalation on oxidative stress in patients with CTS.<bold>Methods: </bold>This double-blind, placebo-controlled study assessed the effects of linalool inhalation on oxidative stress in patients with CTS. Thirty-seven subjects, with and without CTS, were randomized to inhalation of 1% linalool or carrier oil. 1,1-Diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity, systolic blood pressure (sBP), diastolic blood pressure (dBP) and pulse rate were analyzed.<bold>Results: </bold>DPPH inhibition was significantly higher in both experimental groups than in their respective controls. Moreover inhalation of linalool reduced sBP, dBP and pulse rate in the CTS group, and pulse rate in the non-CTS group. However, there were no significant differences among the study groups in nitrite levels, sBP, dBP and pulse rate.<bold>Conclusions: </bold>Inhalation of linalool increases antioxidative activity and reduces blood pressure and pulse rate in patients with CTS.
- Subjects
CARPAL tunnel syndrome; LINALOOL; REACTIVE oxygen species; OXIDATIVE stress; AROMATIC plants; ANTIOXIDANTS; BLOOD pressure; THERAPEUTIC use of antioxidants; HYDROCARBONS; COMPARATIVE studies; HEART beat; RESEARCH methodology; MEDICAL cooperation; RESEARCH; EVALUATION research; RANDOMIZED controlled trials; BLIND experiment; INHALATION administration; THERAPEUTICS
- Publication
BMC Neurology, 2016, Vol 16, p1
- ISSN
1471-2377
- Publication type
journal article
- DOI
10.1186/s12883-016-0541-3