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- Title
Chloroform fraction of Euphorbia maculata has antiplatelet activity via suppressing thromboxane B<sub>2</sub> formation.
- Authors
SE-UK KWON; JI-YOON CHA; HOON-YEON LEE; MINGJIE XIN; SU-JEONG JI; DAE-KI KIM; DO-SIM PARK; MI-KYUNG PYO; YOUNG-MI LEE
- Abstract
Euphorbia maculata (EM) is a traditionally used antidiarrheal, antibacterial, antifungal and antioxidant agent. However, the effects of EM on platelet activity remain to be elucidated. Therefore, the present study investigated the antiplatelet effect of various EM extract fractions on platelet aggregation in rats. The antiplatelet activity of the EM fractions on collagen or adenosine diphosphate (ADP)-induced platelet aggregation was evaluated in vitro and ex vivo. Thromboxane B2 (TXB2) formation, rat-tail bleeding time and coagulation time were also measured. Among the fractions, the chloroform fraction of EM (CFEM) significantly inhibited ADP-induced platelet aggregation in vitro. Furthermore, oral administration of 50 mg/kg CFEM to rats significantly reduced ADP-induced platelet aggregation without increasing the tail bleeding time or coagulation time. In addition, EM significantly inhibited the level of TXB2 formation in a dose-dependent manner. These results suggest that CFEM exhibits antiplatelet activity, without causing bleeding, via the suppression of TXB2 formation. CFEM may be a type of food which has the potential for preventing cardiovascular disease.
- Subjects
CHLOROHYDROCARBONS; ADENOSINE diphosphate; CARDIOVASCULAR disease diagnosis; CARDIOVASCULAR disease prevention; THROMBOXANES
- Publication
Molecular Medicine Reports, 2015, Vol 11, Issue 6, p4255
- ISSN
1791-2997
- Publication type
Article
- DOI
10.3892/mmr.2015.3319