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- Title
Risk of Pulmonary Fibrosis and Persistent Symptoms Post-COVID-19 in a Cohort of Outpatient Health Workers.
- Authors
Fernández-Plata, Rosario; Higuera-Iglesias, Anjarath-Lorena; Torres-Espíndola, Luz María; Aquino-Gálvez, Arnoldo; Velázquez Cruz, Rafael; Camarena, Ángel; Chávez Alderete, Jaime; Romo García, Javier; Alvarado-Vásquez, Noé; Martínez Briseño, David; Castillejos-López, Manuel; Group, Research Working
- Abstract
Background: Infection by SARS-CoV-2 has been associated with multiple symptoms; however, still, little is known about persistent symptoms and their probable association with the risk of developing pulmonary fibrosis in patients post-COVID-19. Methods: A longitudinal prospective study on health workers infected by SARS-CoV-2 was conducted. In this work, signs and symptoms were recorded of 149 health workers with a positive PCR test for SARS-CoV-2 at the beginning of the diagnosis, during the active infection, and during post-COVID-19 follow-up. The McNemar chi-square test was used to compare the proportions and percentages of symptoms between the baseline and each follow-up period. Results: The signs and symptoms after follow-up were cardiorespiratory, neurological, and inflammatory. Gastrointestinal symptoms were unusual at the disease onset, but unexpectedly, their frequency was higher in the post-infection stage. The multivariate analysis showed that pneumonia (HR 2.4, IC95%: 1.5–3.8, p < 0.001) and positive PCR tests still after four weeks (HR 5.3, IC95%: 2.3-12.3, p < 0.001) were factors associated with the diagnosis of post-COVID-19 pulmonary fibrosis in this study group. Conclusions: Our results showed that pneumonia and virus infection persistence were risk factors for developing pulmonary fibrosis post-COVID-19, after months of initial infection.
- Subjects
PULMONARY fibrosis; COVID-19 pandemic; SYMPTOMS; DIAGNOSTIC use of polymerase chain reaction; VIRUS diseases; OCCUPATIONAL mortality; LUNG infections
- Publication
Viruses (1999-4915), 2022, Vol 14, Issue 9, p1843
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v14091843