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- Title
Aging endometrium in young women: molecular classification of endometrial aging-based markers in women younger than 35 years with recurrent implantation failure.
- Authors
Chen, Peigen; Yang, Meng; Wang, Yanfang; Guo, Yingchun; Liu, Yun; Fang, Cong; Li, Tingting
- Abstract
Background: To explore the differences between a population with premature endometrial aging and a population with normal endometrial status in young women with recurrent implantation failure (< 35 years). Methods: Systematic analysis of the endometrium transcriptome of 274 RIF women. The NMF algorithm was used for classification based on endometrial-specific aging markers in CellAge, and the endometrial receptivity, gene expression patterns, and clinical data were compared between the classifications. Results: Two hundred forty-five young RIF women could be divided into two clusters, in which the aging gene expression pattern of cluster 2 was closer to the reference cluster. Cluster 1 was characterized by high immune activity, while cluster 2 was characterized by high metabolic activity. Combined with clinical data, cluster 2 was worse than cluster 1 in window of implantation deviation rate and endometrial receptivity. Conclusion: Premature aging of the endometrium exists in young women with RIF, and premature aging of the endometrium was associated with poor reproductive outcomes.
- Subjects
ENDOMETRIUM; EMBRYO implantation; YOUNG women; PREMATURE aging (Medicine); OLDER people; AGING; POPULATION aging
- Publication
Journal of Assisted Reproduction & Genetics, 2022, Vol 39, Issue 9, p2143
- ISSN
1058-0468
- Publication type
Article
- DOI
10.1007/s10815-022-02578-x