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- Title
A Perspective on the Roles of Adjuvants in Developing Highly Potent COVID-19 Vaccines.
- Authors
Zhang, Naru; Li, Kangchen; Liu, Zezhong; Nandakumar, Kutty Selva; Jiang, Shibo
- Abstract
Several countries have made unremitting efforts to develop an optimal vaccine in the fight against coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). With the increasing occurrence of SARS-CoV-2 variants, current vaccines show decreased neutralizing activities, especially towards the Omicron variant. In this context, adding appropriate adjuvants to COVID-19 vaccines can substantially reduce the number of required doses and improve efficacy or cross-neutralizing protection. We mainly focus on research progress and achievements associated with adjuvanted COVID-19 subunit and inactivated vaccines. We further compare the advantages and disadvantages of different adjuvant formulations in order to provide a scientific reference for designing an effective strategy for future vaccine development.
- Subjects
COVID-19; SARS-CoV-2; COVID-19 vaccines; SARS-CoV-2 Omicron variant
- Publication
Viruses (1999-4915), 2022, Vol 14, Issue 2, p387
- ISSN
1999-4915
- Publication type
Article
- DOI
10.3390/v14020387