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- Title
Effect of diabetes on scintigraphic infarct size in STEMI patients undergoing primary angioplasty.
- Authors
De Luca, Giuseppe; Parodi, Guido; Sciagrà, Roberto; Bellandi, Benedetta; Vergara, Ruben; Migliorini, Angela; Valenti, Renato; Antoniucci, David
- Abstract
Background It has been shown that among patients with ST-segment elevation myocardial infarction (STEMI), diabetes is associated with a significantly higher mortality, mainly because of impaired reperfusion. However, few data have been reported so far on infarct size as evaluated by well-refined techniques, such as nuclear imaging techniques. Therefore, the aim of the current study was to investigate the effect of diabetes in infarct size as evaluated by myocardial scintigraphy in a large cohort of STEMI patients undergoing primary PCI. Methods We included 830 STEMI patients undergoing primary PCI. Infarct size was evaluated at 30 days by technetium-99 m-sestamibi. A logistic regression analysis was performed to determine the relation between diabetes and infarct size (as above the median) after correction for baseline confounding factors. Results A total of 115 (13.8%) out of 830 patients suffered from diabetes. Diabetic patients were older ( p < 0.001), with larger prevalence of female gender ( p = 0.006) and hypertension ( p = 0.001) but were less often smokers ( p = 0.003). Diabetic patients had more often preprocedural thrombolysis in myocardial infarction grade 3 flow ( p = 0.034) and less complete ST-segment resolution ( p = 0.009). No difference was observed in scintigraphic infarct size between diabetes and control patients ( p = 0.6)), which was confirmed at multivariate analysis after correction for baseline confounding factors (Adjusted OR [95% CI] = 0.87 [0.57-1.31, p = 0.51). Conclusion Our study showed that among STEMI patients undergoing primary angioplasty, diabetes did not affect infarct size as compared with non-diabetic patients. Copyright © 2014 John Wiley & Sons, Ltd.
- Publication
Diabetes/Metabolism Research & Reviews, 2015, Vol 31, Issue 3, p322
- ISSN
1520-7552
- Publication type
Article
- DOI
10.1002/dmrr.2620