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- Title
Hepatocellular carcinoma patients with increased oxidative stress levels are prone to recurrence after curative treatment: a prospective case series study using the d-ROM test.
- Authors
Suzuki, Yusuke; Imai, Kenji; Takai, Koji; Hanai, Tatsunori; Hayashi, Hideki; Naiki, Takafumi; Nishigaki, Yoichi; Tomita, Eiichi; Shimizu, Masahito; Moriwaki, Hisataka
- Abstract
Purpose: Oxidative stress plays an important role in liver carcinogenesis. To determine the impact of oxidative stress on the recurrence of stage I/II hepatocellular carcinoma (HCC) after curative treatment, we conducted a prospective case series analysis. Methods: This study included 45 consecutive patients with stage I/II HCC, who underwent curative treatment by surgical resection or radiofrequency ablation at Gifu Municipal Hospital from 2006 to 2007. In these 45 cases, recurrence-free survival was estimated using the Kaplan-Meier method. The factors contributing to HCC recurrence, including the serum levels of derivatives of reactive oxygen metabolites (d-ROM) as an index of oxidative stress, were subjected to univariate and multivariate analyses using the Cox proportional hazards model. Results: The serum levels of d-ROM ( P = 0.0231), α-fetoprotein (AFP, P = 0.0274), and fasting plasma glucose ( P = 0.0400) were significantly associated with HCC recurrence in the univariate analysis. Multivariate analysis showed that the serum levels of d-ROM (hazard ratio [HR] 1.0038, 95 % confidence interval [CI] 1.0002-1.0071, P = 0.0392) and AFP (HR 1.0002, 95 % CI 1.0000-1.0003, P = 0.0316) were independent predictors of HCC recurrence. Kaplan-Meier analysis showed that recurrence-free survival was low in patients with high serum d-ROM (≥570 Carr U, P = 0.0036) and serum AFP (≥40 ng/dL, P = 0.0185) levels. Conclusions: The serum levels of d-ROM and AFP can be used for screening patients with a high risk for HCC recurrence. Patients who show increased levels of these factors require careful surveillance.
- Subjects
LIVER cancer; OXIDATIVE stress; CANCER relapse; CARCINOGENESIS; CATHETER ablation; ONCOLOGIC surgery; LONGITUDINAL method
- Publication
Journal of Cancer Research & Clinical Oncology, 2013, Vol 139, Issue 5, p845
- ISSN
0171-5216
- Publication type
Article
- DOI
10.1007/s00432-013-1389-1