We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Base-Promoted Intramolecular Addition of Vinyl Cyclopropanecarboxamides to Access Conformationally Restricted Aza[3.1.0]bicycles.
- Authors
Li, Jingya; Zhang, Zhiguo; Chen, Liming; Li, Mengjuan; Zhang, Xingjie; Zhang, Guisheng
- Abstract
3-Azabicyclo[3.1.0]hexanes are common structural components in natural products and bioactive compounds. Traditionally, the metal-mediated cyclopropanation domino reaction of chain enzymes is the most commonly used strategy for the construction of this type of aza[3.1.0]bicycle derivative. In this study, a base-promoted intramolecular addition of alkenes used to deliver conformationally restricted highly substituted aza[3.1.0]bicycles is reported. This reaction was tailor-made for saturated aza[3.1.0] bicycle-containing fused bicyclic compounds that may be applied in the development of concise and divergent total syntheses of bioactive compounds.
- Subjects
DOMINO toppling; INTRAMOLECULAR proton transfer reactions; BICYCLES; BICYCLIC compounds; BIOACTIVE compounds; NATURAL products
- Publication
Molecules, 2023, Vol 28, Issue 9, p3691
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules28093691