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- Title
Continued RAG expression in late stages of B cell development and no apparent re-induction after immunization.
- Authors
Yu, Wong; Nagaoka, Hitoshi; Jankovic, Mila; Misulovin, Ziva; Suh, Heikyung; Rolink, Antonius; Melchers, Fritz; Meffre, Eric; Nussenzweig, Michael C.
- Abstract
Presents a study to investigate the regulation of recombination-activating genes (RAG) expression in transgenic mice carrying a bacterial artificial chromosome that encodes a green fluorescent protein reporter instead of RAG2. Expression of the reporter in all immature B cells in the bone marrow and spleen; Suggestion of a new model for the mechanisms that regulate allelic exclusion, receptor editing and tolerance.
- Subjects
B cell differentiation; TRANSGENIC mice; GENE expression; GENETIC research; SCIENTIFIC experimentation
- Publication
Nature, 1999, Vol 400, Issue 6745, p682
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/23287