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- Title
The transcription factor NF-ATc is essential for cardiac valve formation.
- Authors
Ranger, Ann M.; Grusby, Michael J.; Hodge, Martin R.; Gravallese, Ellen M.; De la Brousse, Fabienne Charles; Hoey, Tim; Mickanin, Craig; Baldwin, H. Scott; Glimcher, Laurie H.
- Abstract
Presents research which reported that mice with a disruption of the NF-ATc gene show a defect in cardiac morphogenesis. What nuclear factor of activated T cells (NF-AT) is; Normal tricuspid and mitral valve morphogenesis; Control of nuclear translocation of NF-ATc in cardiac endothelial cells; Role of NF-ATc in signal transduction processes for cardiac valve formation.
- Subjects
HEART development regulation; HEART valve diseases; COMPARATIVE embryology; MICE; GENETICS
- Publication
Nature, 1998, Vol 392, Issue 6672, p186
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/32426