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- Title
Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function.
- Authors
Cruz-Munoz, Mario-Ernesto; Dong, Zhongjun; Shi, Xiaochu; Zhang, Shaohua; Veillette, André
- Abstract
CRACC is a self-associating member of the signaling lymphocytic activation molecule family that is expressed on cells of the immune system, including natural killer cells and activated T cells. Here we examine the function and mechanism of action of CRACC using several complementary approaches, including the generation of a CRACC-deficient mouse. Our results demonstrate that CRACC positively regulated natural killer cell functions by a mechanism dependent on the adaptor EAT-2 but not the related adaptor SAP. However, in the absence of EAT-2, CRACC potently inhibited natural killer cell function. CRACC was also inhibitory in T cells, which are typically devoid of EAT-2. Thus, CRACC can exert activating or inhibitory influences on cells of the immune system depending on cellular context and the availability of effector proteins.
- Publication
Nature Immunology, 2009, Vol 10, Issue 3, p297
- ISSN
1529-2908
- Publication type
Article
- DOI
10.1038/ni.1693